• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The invention relates to a device for the visual detection of analytes in an analyte or fluid sample originating from the human organism, comprising a first shell and a second shell connectable thereto, which together form a cassette, wherein at least one of the two shells at least one receptacle for a is arranged with a sample receiving portion and a test section provided test strip, wherein in the opposite shell in each case above a recording sample task window (3) and spaced therefrom a control window (4) are arranged such that when inserted test strip the sample task window (3) above the Sample holding section and the control window (4) are located above the test section. In each case at least one receptacle (5) for a test strip and a sample task window (3) and a control window (4) are arranged in the first shell (2) and the second shell (2 ').
    公开号:CH712081A2
    申请号:CH01597/16
    申请日:2016-12-06
    公开日:2017-07-31
    发明作者:Protzek Christoph
    申请人:Protzek Ges Für Biomedizinische Technik Mbh；
    IPC主号:
    专利说明:

    Description: [0001] The invention relates to a device for the visual detection of analytes in an analyte or fluid sample originating from the human organism, according to the preamble of patent claim 1.
    Devices for the detection of analytes in a liquid sample, e.g. of drugs, drugs or antibodies as a sign of certain diseases in a body fluid, are known in different versions. There is particular interest in such devices, which can also be used outside of a laboratory. These must be portable and easy to use and deliver a reliable result in a short time. In particular, for the conduct of tests on drug use or drug abuse or the like by the police, a device is required, which allows for such a test even outdoors in different changing light conditions, weather conditions and temperatures. In DE 20 2014 002 369 U1 a device is proposed for this purpose into which a test cassette can be introduced and which is provided with a light source, by means of which the lower wall of the test cassette consisting of a translucent plastic and the test area of the test strip arranged in the test cassette are irradiated and the test result illuminates. The test cassette is designed to perform a lateral flow immunoassay and consists of a lower lid and an upper lid. Enclosed by these two lids, the test cassette contains a test strip which is held in place within a receptacle. In the upper lid is located above the sampler of the test strip, a filling opening through which a liquid sample can be entered. Over the middle test area of the test strip there is a control window, through which the test result can be read. Such cassettes have proven themselves in mobile use. However, a disadvantage of the previously known cassettes is that only a limited number of active substances can be detected, which is why several test cassettes equipped with differently aligned test strips have to be carried along.
    Here, the invention seeks to remedy this. The invention is based on the object to provide a device for the visual detection of analytes in a liquid sample, which is suitable for mobile use and which allows analysis for a larger number of analytes in a liquid sample. According to the invention, this object is achieved by a device having the features of the characterizing part of patent claim 1.
    The invention provides a device for the visual detection of analytes in a liquid sample, which can be used mobile and which enables detection of a larger number of analytes in a liquid sample. The fact that at least one receptacle for a test strip and a sample task window and a control window are arranged in the first shell and the second shell, the admission of several different set test strips in a cassette with small dimensions is possible.
    In a further development of the invention, the receptacle for a test strip is formed in each case by integrally formed on a shell webs, between which a test strip is fixed. This allows a simple, cost-effective implementation of the recording.
    In an embodiment of the invention, at least one hold-down is formed on a receptacle for a test strip opposite shell, which is arranged between the webs, such that an inserted into the receptacle test strip is pressed by the hold-down against the test strip receiving shell. As a result, a good fixation of the test strip is achieved within the device.
    In an advantageous embodiment of the invention, two receptacles for a test strip as well as two sample application windows and two control windows are arranged adjacent to each other in the first shell and the second shell. This makes it possible to apply four different test strips within one and the same device. With a regularly possible detection of three analytes per test strip, a visual detection of twelve analytes by means of one and the same device is made possible, which has only small dimensions due to the design according to the invention.
    In a further development of the invention, the shells are designed to be translucent, at least in the area of the receptacles for a test strip. As a result, a fluoroscopy of the test strip is possible, whereby the reading accuracy is increased. Preferably, the shells are made of translucent plastic.
    In a further embodiment of the invention, at least one shell on its at least one receptacle for a test strip opposite outside a flat depression. As a result, the translucency is increased at this point. In addition, the two-dimensional depression forms a receptacle for a barcode label for the provision of specific information indicating the equipment of the device.
    In a further embodiment of the invention, the two shells are provided with mutually corresponding connector elements, via which the two shells are connected to each other. This allows a simple assembly of the respective device with test strips. Advantageously, the connector elements are designed such that a non-detachable connection is achieved after assembly of the two shells. As a result, a subsequent manipulation of the device equipped with the test strip is prevented.
    In development of the invention, the two shells are identical. As a result, the production costs are minimized. In addition, the required storage capacities are reduced.
    Other developments and refinements of the invention are specified in the remaining subclaims. An embodiment of the invention is illustrated in the drawings and will be described in detail below. Show it:
    1 shows the schematic representation of a device for the visual detection of analytes in a liquid sample;
    FIG. 2 is a plan view of the upper shell of the device of FIG. 1; FIG.
    FIG. 3 shows the illustration of the upper shell according to FIG. 2 in a view from below; FIG.
    4 shows the representation of the upper shell of Figure 3 in section IV-IV ..;
    FIG. 5 is a side view of the upper shell of FIG. 2; FIG.
    Fig. 6 is a schematic representation of the lower disc of the device of Figure 1 in plan view.
    Figure 7 shows the representation of the lower shell of Figure 6 in section VII-VII ..;
    FIG. 8 is a side view of the lower shell of FIG. 6; FIG.
    Fig. 9 shows the representation of the lower shell of Fig. 6 in the view from below and
    Fig. 10 is a schematic representation of the device of Fig. 1 with inserted test strip in the step cross-section.
    The selected as an embodiment device for the visual detection of analytes in a liquid sample consists essentially of a first shell 2 and a second shell 3, through which a cassette 1 is formed, which receives four test strips 7.
    The first shell 2 is formed as a substantially rectangular plastic injection molded part, which is provided with an outer peripheral edge 21. On a first longitudinal half 22 of the first shell 2 are adjacent to each other two funnel-like sample introduction window 3 is introduced. Spaced to these two sample application window 3 are in the first shell 2 on the longitudinal central axes lying spaced from this two elongated control window 4 is arranged. Between a sample application window 3 and a control window 4 are each spaced two web-like hold-down 52 formed on the first shell 2. The first longitudinal half 22 framing on the first shell 2 are further spaced from each other six first connector elements 24 integrally formed.
    Also, the second longitudinal half 23 of the first shell 2 is framed by six first connector elements 24, wherein a total of nine on the first shell 2 connector elements 24 are present. On the second longitudinal half 23 adjacent to each other two receptacles 5 are arranged for each test strip 7. The receptacles 5 are formed by webs 51, which are adapted to the contour of a test strip 7 and limit this. On its upper side opposite the receptacles 5, a rectangular depression 6 for receiving a barcode label is formed in the first shell 2 on its second longitudinal half 23.
    In Figs. 7 to 9, the lower, second shell 2 'of the cassette 1 is shown. The second shell 2 'is formed in the embodiment identical to the first shell 2, wherein second connector elements 25 are arranged, which correspond to the first connector elements 24 of the first shell 2 and together with these can form a non-detachable connector.
    In Fig. 10, the device according to the invention according to FIG. 1 with inserted test strip 7 is shown in a stepped section. The test strip 7 has a carrier film 70 on which a sample receiving section 71 is arranged at one end. Immediately adjacent and partially under the sample receiving section 71 is on the carrier film 70, an antibody coating 72 which contains antibodies which are conjugated with gold particles and which match an analyte to be detected or to an antigen of this analyte and can enter into an immunological reaction. The antibody coating portion 72 is followed by a test portion 73 formed in the form of a membrane spaced from each other by a test line 731 and a control line 732 formed by and contained in an antigen-containing reagent for detecting a particular analyte Task of a sample are invisible. The sample receiving section 71 of the test strip 7 is located below the sample application window 3 and the test section 73 is located below the control window 7 of the respective associated shell 2, 2 '. In Fig. 10, only a test line 731 is shown.
    When performing a lateral flow assay, the test line 731 indicates the result of the test, the control line 732 indicates whether a sufficient amount of sample has been abandoned, so whether the test is valid. At its opposite end of the sample receiving portion 71 an Absorbaabschnitt 74 is disposed on the test strip 7.
    Before carrying out a test, no lines 731.732 are visible. In carrying out a test, a sample volume of a sample liquid is passed through a sample application window 3 onto the sample receiving portion 71 of a sample
    权利要求:
    Claims (9)
    [1]
    each test strip 7 abandoned. By capillary action, the sample liquid flows in the direction of the test section 73 and is attracted by the Absorbaabschnitt 74 at the other end of the test strip 7. In this case, the liquid is distributed homogeneously in the test section 73. It first comes into contact with the antibody covering section 72, in which antibodies conjugated with gold particles are in the standardized (metered) amount to the antigen of a detected analyte. The antibodies have different binding activity for different analytes (drugs). The antibodies conjugated with gold particles are carried along by the sample liquid which flows through the test section 73. If the sample liquid does not contain the analyte to be determined, the antigens of the analyte located in the region of the test line 731 are bound by the antibodies entrained by the sample liquid as it flows through the test section 73 and a visible test line 773 is formed which is blocked by the antibodies conjugated gold particles gets a red or brown color. The test result is negative. If the sample liquid contains the analyte to be detected, its antigens are already bound by the antibodies in the area of the antibody covering section 72 of the test strip 7 and it is no longer possible to attach in the test section 73, so that no visible test line 731 is formed. The test result is positive here. Control line 732 indicates if the test is valid. In Fig. 1, the test result from two test strips is visible. Thereafter, the test is negative with respect to the three corresponding analytes; on the second, inner strip, two test lines 731 have not formed in color - with respect to the analytes assigned to these test lines 731, the test is therefore positive. In another embodiment, the - in the form shown in the figures (3) - conically narrow test sample windows remain both completely open, as well as identify a closed bottom, in which a gap or a differently sized passage opening is incorporated, the is smaller than this soil and the goal is to influence the rate of flow of different viscous sample liquids onto the test membrane above its size and dimension. claims
    An apparatus for the visual detection of analytes in an analyte or fluid sample from a human organism, comprising a first tray and a second tray connectable thereto forming a cassette together, wherein at least one of the two cups has at least one receptacle for one with a sample receiving portion and a test section provided test strip is arranged, wherein in the opposite shell each have a sample task window and spaced therefrom a control window are arranged such that when the test strip is inserted the sample task window on the sample receiving section and the control window on the test section, characterized in that in each case at least one receptacle (5) for a test strip (7) and a sample task window (3) and a control window (4) are arranged in the first shell (2) and the second shell (2 ").
    [2]
    2. Apparatus according to claim 1, characterized in that the receptacle (5) for a test strip (7) in each case by a shell (2, 2) integrally formed webs (51) is formed, between which the test strip (7) is fixable.
    [3]
    3. A device according to claim 2, characterized in that on the receptacle (5) for a test strip (7) opposite shell (2 ', 2) at least one hold-down (52) is formed, which is arranged between the webs (51) in such a way that a test strip (7) inserted into the receptacle (5) is pressed by the hold-down device (52) against the dish (2, 2 ') receiving the test strip (7).
    [4]
    4. Device according to one of the preceding claims, characterized in that in the first shell (2) and the second shell (2) adjacent to each other two receptacles (5) for a test strip (7) and two sample application window (3) and two control windows (4) are arranged.
    [5]
    5. Device according to one of the preceding claims, characterized in that the shells (2, 2 ') are designed to be translucent at least in the region of the receptacles (5) for a test strip (7).
    [6]
    6. Apparatus according to claim 5, characterized in that the shells (2, 2 ') are made of translucent plastic.
    [7]
    7. Device according to one of the preceding claims, characterized in that at least one shell (2, 2 ') on its at least one receptacle (5) for a test strip (7) opposite the outside a flat depression (6).
    [8]
    8. Device according to one of the preceding claims, characterized in that the two shells (2, 2 ') with mutually corresponding connector elements (24,25) are provided, via which the two shells (2, 2') are connectable to each other.
    [9]
    9. Device according to one of the preceding claims, characterized in that the two shells (2, 2 ') are identical.
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    同族专利:
    公开号 | 公开日
    CH712081B1|2020-08-14|
    DE202016100261U1|2016-03-04|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    DE202014002369U1|2013-03-23|2014-04-29|Ingenieurbüro Protzek & Kollegen Gbr|Device for the detection of analytes in a liquid sample|PL3287785T3|2016-08-24|2019-05-31|Protzek Ges Fuer Biomedizinische Technik Gmbh|Device for visual detection of analytes in a liquid sample|
    DE202017102779U1|2017-05-09|2017-06-22|Protzek Gesellschaft für Biomedizinische Technik GmbH|Device for the visual detection of analytes in a liquid sample|
    DE102019117413A1|2019-06-27|2020-12-31|Testo SE & Co. KGaA|Flow test unit, set and use of a flow test unit to carry out a detection reaction|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    DE202016100261.3U|DE202016100261U1|2016-01-21|2016-01-21|Device for the visual detection of analytes in a liquid sample|
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